Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Nat Rev Neurol. 2011 May 24;7(7):410-4. doi: 10.1038/nrneurol.2011.76.

The ethics of informed consent in Alzheimer disease research.

Author information

  • Center for Bioethics and Social Sciences in Medicine, University of Michigan, 300 North Ingalls 7C27, Ann Arbor, Michigan 48109, USA. scottkim@med.umich.edu

Abstract

Clinical research on Alzheimer disease (AD) is much needed but requires the participation of patients with substantial cognitive impairment who have difficulty providing informed consent. Despite decades of debate, policies regulating such research are not well-defined. Although numerous studies have underscored the difficulties of obtaining informed consent for clinical research from patients compromised by AD, there is also increasing evidence that such individuals and their surrogates can make decisions about research participation that are consistent with the patients' values. Policy discussions and future research should consider how the ethical reservations about enrolling incapacitated patients in research could be mitigated by developing ways to promote the congruence between surrogates' decisions and patients' values.

PMID:
21610690
[PubMed - indexed for MEDLINE]
PMCID:
PMC3475518
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Write to the Help Desk