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Methods Enzymol. 2011;498:137-52. doi: 10.1016/B978-0-12-385120-8.00006-1.

SynBioSS-aided design of synthetic biological constructs.

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  • 1Department of Chemical Engineering and Materials Science, and Digital Technology Center, University of Minnesota, Minneapolis, Minnesota, USA.

Abstract

We present walkthrough examples of using SynBioSS to design, model, and simulate synthetic gene regulatory networks. SynBioSS stands for Synthetic Biology Software Suite, a platform that is publicly available with Open Licenses at www.synbioss.org. An important aim of computational synthetic biology is the development of a mathematical modeling formalism that is applicable to a wide variety of simple synthetic biological constructs. SynBioSS-based modeling of biomolecular ensembles that interact away from the thermodynamic limit and not necessarily at steady state affords for a theoretical framework that is generally applicable to known synthetic biological systems, such as bistable switches, AND gates, and oscillators. Here, we discuss how SynBioSS creates links between DNA sequences and targeted dynamic phenotypes of these simple systems.

Copyright © 2011 Elsevier Inc. All rights reserved.

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