Format

Send to:

Choose Destination
See comment in PubMed Commons below
Magn Reson Imaging. 2011 Dec;29(10):1410-6. doi: 10.1016/j.mri.2011.04.006. Epub 2011 May 20.

Non-Gaussian diffusion imaging: a brief practical review.

Author information

  • 1Physics Department, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy. silvia.desantis@roma1.infn.it

Abstract

The departure from purely mono-exponential decay of the signal, as observed from brain tissue following a diffusion-sensitized sequence, has prompted the search for alternative models to characterize these unconventional water diffusion dynamics. Several approaches have been proposed in the last few years. While multi-exponential models have been applied to characterize brain tissue, several unresolved controversies about the interpretations of the results have motivated the search for alternative models that do not rely on the Gaussian diffusion hypothesis. In this brief review, diffusional kurtosis imaging (DKI) and anomalous diffusion imaging (ADI) techniques are addressed and compared with diffusion tensor imaging. Theoretical and experimental issues are briefly described to allow readers to understand similarities, differences and limitations of these two non-Gaussian models. However, since the ultimate goal is to improve specificity, sensitivity and spatial localization of diffusion MRI for the detection of brain diseases, special attention will be paid on the clinical feasibility of the proposed techniques as well as on the context of brain pathology investigations.

Copyright © 2011 Elsevier Inc. All rights reserved.

PMID:
21601404
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk