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Pulm Pharmacol Ther. 2011 Oct;24(5):513-24. doi: 10.1016/j.pupt.2011.05.002. Epub 2011 May 12.

Small animals models for drug discovery.

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  • 1Meakins Christie Laboratories, McGill University, 3626 St. Urbain St., Montreal, Quebec, Canada. james.martin@mcgill.ca

Abstract

There has been an explosion of studies of animal models of asthma in the past 20 years. The elucidation of fundamental immunological mechanisms underlying the development of allergy and the complex cytokine and chemokines networks underlying the responses have been substantially unraveled. Translation of findings to human asthma have been slow and hindered by the varied phenotypes that human asthma represents. New areas for expansion of modeling include virally mediated airway inflammation, oxidant stress, and the interactions of stimuli triggering innate immune and adaptive immune responses.

Copyright © 2011 Elsevier Ltd. All rights reserved.

PMID:
21601000
[PubMed - indexed for MEDLINE]
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