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Bioorg Med Chem Lett. 2011 Jun 15;21(12):3693-8. doi: 10.1016/j.bmcl.2011.04.085. Epub 2011 Apr 24.

α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging.

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  • 1Edison Pharmaceuticals, Inc., Mountain View, CA 94043, USA. bshrader@edisonpharma.com

Abstract

We report that α-tocotrienol quinone (ATQ3) is a metabolite of α-tocotrienol, and that ATQ3 is a potent cellular protectant against oxidative stress and aging. ATQ3 is orally bioavailable, crosses the blood-brain barrier, and has demonstrated clinical response in inherited mitochondrial disease in open label studies. ATQ3 activity is dependent upon reversible 2e-redox-cycling. ATQ3 may represent a broader class of unappreciated dietary-derived phytomolecular redox motifs that digitally encode biochemical data using redox state as a means to sense and transfer information essential for cellular function.

Copyright © 2011 Elsevier Ltd. All rights reserved.

PMID:
21600768
[PubMed - indexed for MEDLINE]
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