Bioorg Med Chem Lett. 2011 Jun 15;21(12):3693-8. Epub 2011 Apr 24.

α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging.

Shrader WD, Amagata A, Barnes A, Enns GM, Hinman A, Jankowski O, Kheifets V, Komatsuzaki R, Lee E, Mollard P, Murase K, Sadun AA, Thoolen M, Wesson K, Miller G.

Source

Edison Pharmaceuticals, Inc., Mountain View, CA 94043, USA. bshrader@edisonpharma.com

Abstract

We report that α-tocotrienol quinone (ATQ3) is a metabolite of α-tocotrienol, and that ATQ3 is a potent cellular protectant against oxidative stress and aging. ATQ3 is orally bioavailable, crosses the blood-brain barrier, and has demonstrated clinical response in inherited mitochondrial disease in open label studies. ATQ3 activity is dependent upon reversible 2e-redox-cycling. ATQ3 may represent a broader class of unappreciated dietary-derived phytomolecular redox motifs that digitally encode biochemical data using redox state as a means to sense and transfer information essential for cellular function.

PMID:: 21600768; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Molecular Biology Databases

1,4-BENZOQUINONE - HSDB

Supplemental Content

Related citations

Alpha-tocotrienol provides the most potent neuroprotection among vitamin E analogs on cultured striatal neurons. [Neuropharmacology. 2004]
Alpha-tocotrienol provides the most potent neuroprotection among vitamin E analogs on cultured striatal neurons.
Osakada F, Hashino A, Kume T, Katsuki H, Kaneko S, Akaike A. Neuropharmacology. 2004 Nov; 47(6):904-15.
Review Structural and functional changes in proteins induced by free radical-mediated oxidative stress and protective action of the antioxidants N-tert-butyl-alpha-phenylnitrone and vitamin E. [Ann N Y Acad Sci. 1998]
Review Structural and functional changes in proteins induced by free radical-mediated oxidative stress and protective action of the antioxidants N-tert-butyl-alpha-phenylnitrone and vitamin E.
Butterfield DA, Koppal T, Howard B, Subramaniam R, Hall N, Hensley K, Yatin S, Allen K, Aksenov M, Aksenova M, et al. Ann N Y Acad Sci. 1998 Nov 20; 854:448-62.
Comparative effects of alpha-tocopherol and gamma-tocotrienol against hydrogen peroxide induced apoptosis on primary-cultured astrocytes. [J Neurol Sci. 2006]
Comparative effects of alpha-tocopherol and gamma-tocotrienol against hydrogen peroxide induced apoptosis on primary-cultured astrocytes.
Mazlan M, Sue Mian T, Mat Top G, Zurinah Wan Ngah W. J Neurol Sci. 2006 Apr 15; 243(1-2):5-12. Epub 2006 Jan 27.
Towards a modern definition of vitamin E-evidence for a quinone hypothesis. [Bioorg Med Chem Lett. 2012]
Towards a modern definition of vitamin E-evidence for a quinone hypothesis.
Shrader WD, Amagata A, Barnes A, Hinman A, Jankowski O, Lee E, Kheifets V, Komatsuzaki R, Mollard P, Murase K, et al. Bioorg Med Chem Lett. 2012 Jan 1; 22(1):391-5. Epub 2011 Nov 15.
Review Aging brain: prevention of oxidative stress by vitamin E and exercise. [ScientificWorldJournal. 2009]
Review Aging brain: prevention of oxidative stress by vitamin E and exercise.
Asha Devi S. ScientificWorldJournal. 2009 May 22; 9:366-72. Epub 2009 May 22.

See reviews... See all...

Cited by 1 PubMed Central article

Oxidative stress in neurodegenerative diseases: mechanisms and therapeutic perspectives. [Oxid Med Cell Longev. 2011]
Oxidative stress in neurodegenerative diseases: mechanisms and therapeutic perspectives.
Melo A, Monteiro L, Lima RM, Oliveira DM, Cerqueira MD, El-Bachá RS. Oxid Med Cell Longev. 2011; 2011:467180. Epub 2011 Nov 24.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

α-Tocotrienol quinone modulates oxidative stress response and the biochemistry o...
α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging.
Bioorg Med Chem Lett. 2011 Jun 15 ;21(12):3693-8. Epub 2011 Apr 24 .

PubMed
Social modulation of pain as evidence for empathy in mice.
Social modulation of pain as evidence for empathy in mice.
Science. 2006 Jun 30 ;312(5782):1967-70.

PubMed
Infants' preferences for toys, colors, and shapes: sex differences and similarit...
Infants' preferences for toys, colors, and shapes: sex differences and similarities.
Arch Sex Behav. 2010 Dec ;39(6):1261-73. Epub 2010 Mar 16 .

PubMed
Effects of gum resin of Boswellia serrata in patients with chronic colitis.
Effects of gum resin of Boswellia serrata in patients with chronic colitis.
Planta Med. 2001 Jul ;67(5):391-5.

PubMed
Mass spectrometry analysis of hepcidin peptides in experimental mouse models.
Mass spectrometry analysis of hepcidin peptides in experimental mouse models.
PLoS One. 2011 Mar 8 ;6(3):e16762.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging.

Source

Abstract

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Molecular Biology Databases

Supplemental Content

Related citations

Cited by 1 PubMed Central article

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information