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Mech Ageing Dev. 2011 Aug;132(8-9):389-94. doi: 10.1016/j.mad.2011.04.011. Epub 2011 May 11.

Cdk5: mediator of neuronal development, death and the response to DNA damage.

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  • 1Department of Pharmacology, Emory University School of Medicine, Whitehead Bldg., Rm505L 615 Michael St., Atlanta, GA 30322, USA.

Abstract

In the central nervous system, cyclin-dependent kinase 5 (Cdk5), an unusual member of the Cdk family, is implicated in the regulation of various physiological processes ranging from neuronal survival, migration and differentiation, to synaptogenesis, synaptic plasticity and neurotransmission. Dysregulation of this kinase has been demonstrated to play a critical role in the pathogenic process of neurodegenerative disorders. DNA damage is emerging as an important pathological component in various neurodegenerative conditions. In this review, we discuss the recent progress regarding the regulation and roles of Cdk5 under physiological conditions, and its dysregulation under pathological conditions, especially in neuronal death mediated by DNA damage.

Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

PMID:
21600237
[PubMed - indexed for MEDLINE]
PMCID:
PMC3179526
Free PMC Article

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