Chemotherapy. 1990;36(3):209-14.

In vitro effect of YTR (tazobactam) on plasmid and chromosomally mediated beta-lactamases.

Source

Department of Medical Microbiology, State University of Limburg, Maastricht, The Netherlands.

Abstract

The effect of tazobactam on the piperacillin susceptibility and on the beta-lactamase activity of different strains and species was evaluated. A synergistic effect was observed on the piperacillin susceptibility for all microorganisms tested, irrespective of the type and/or amount of beta-lactamase produced. Addition of gentamicin resulted in a further reduction of the piperacillin MIC. The enzyme activity after induction with piperacillin alone or in combination with tazobactam (4 mg/l) was quite similar.

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Cited by 3 PubMed Central articles

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