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J Am Chem Soc. 2011 Jun 15;133(23):8870-3. doi: 10.1021/ja203198y. Epub 2011 May 24.

Redox-switchable surface for controlling peptide structure.

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  • 1Department of Chemistry, Carolina Center for Cancer Nanotechnology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.


A general surface chemistry strategy is described for the development of a new switchable material. The method modulates a surface-immobilized-molecules structure by using two orthogonal "click" reactions based on Huisgen cycloaddition and oxime chemistry, where the oxime linkage is redox active and switchable. We demonstrate this strategy by developing a noninvasive, biocompatible, in situ surface chemistry that is able to modulate the affinity of a cell-adhesive peptide to cell integrin receptors to study dynamic cell adhesion and cell migration in real time and as a new hide-and-reveal strategy for application in new types of smart biofouling biomaterials.

© 2011 American Chemical Society

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