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Clin Pharmacol Ther. 2011 Jun;89(6):784-5. doi: 10.1038/clpt.2011.30.

The phenotype standardization project: improving pharmacogenetic studies of serious adverse drug reactions.

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  • 1Wolfson Centre for Personalised Medicine, University of Liverpool, Liverpool, UK.


The ability to predict the risk for serious drug-induced adverse reactions first requires a large patient database for characterization and validation of genetic markers. The Phenotype Standardization Project (PSP) was initiated to standardize phenotypic definitions, thereby facilitating much-needed recruitment without sacrificing the reliability of patient classification. Three phenotypes have been considered in this initial phase: drug-induced liver injury, drug-induced skin injury, and drug-induced torsade de pointes.

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