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Methods Mol Biol. 2011;722:1-9. doi: 10.1007/978-1-61779-040-9_1.

Genome sequencing and assembly.

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  • 1University of Massachusetts, Amkebt, MA, USA.

Abstract

Decoding the genome sequence is becoming a fundamental tool for molecular, genetic, and genomic studies. This chapter reviews the history of DNA sequencing and technical principles of different sequencing platforms, and compares the strengths and weaknesses of different techniques for high-throughput genome sequencing applications are compared. It also covers brief descriptions on genome assembly and its validation.

PMID:
21590409
[PubMed - indexed for MEDLINE]
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