In vitro and in vivo trypanocidal activity of native plants from the Yucatan Peninsula

Parasitol Res. 2012 Jan;110(1):31-5. doi: 10.1007/s00436-011-2447-8. Epub 2011 May 17.

Abstract

Ethanol extracts of Senna villosa, Serjania yucatanensis, Byrsonima bucidaefolia, and Bourreria pulchra were evaluated for their in vitro activity against epimastigotes and trypomastigotes of Trypanosoma cruzi. Results showed that the leaf extracts of S. yucatanensis and B. pulchra were the most active against epimastigotes (IC(100) = 100 μg/mL) and trypomastigotes of T. cruzi (95% or more reduction in the number of parasites at 100 and 50 μg/mL). However, only the leaf extract of S. yucatanensis showed significant trypanocidal activity when tested in vivo, reducing 75% of the parasitemia in infected mice at 100 mg/kg. This same extract inhibited the egress of trypomastigotes from infected cells and proved not to be cytotoxic (IC(50) = 318.8 ± 2.3 μg/mL).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antiprotozoal Agents / administration & dosage*
  • Antiprotozoal Agents / isolation & purification
  • Antiprotozoal Agents / pharmacology*
  • Chagas Disease / drug therapy
  • Disease Models, Animal
  • Female
  • Ferns / chemistry*
  • Humans
  • Inhibitory Concentration 50
  • Mexico
  • Mice
  • Mice, Inbred BALB C
  • Parasitemia / drug therapy
  • Parasitic Sensitivity Tests
  • Plant Extracts / administration & dosage*
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology*
  • Treatment Outcome
  • Trypanosoma cruzi / drug effects*

Substances

  • Antiprotozoal Agents
  • Plant Extracts