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Infect Dis Obstet Gynecol. 2011;2011:567408. doi: 10.1155/2011/567408. Epub 2011 Apr 7.

Association of low-risk human papillomavirus infection with male circumcision in young men: results from a longitudinal study conducted in Orange Farm (South Africa).

Author information

  • 1CESP, INSERM-UVSQ, UMRS 1018, Hôpital Paul Brousse, 16 avenue Paul Vaillant-Couturier, 94807 Villejuif Cedex, France.

Abstract

BACKGROUND:

Low-Risk Human Papillomavirus (LR-HPV) genotypes 6 and 11 cause genital warts. This study investigated the association of LR-HPV infection with male circumcision (MC).

METHODS:

We used data from the South African MC trial conducted among young men. Urethral swabs, collected among intervention (circumcised) and control (uncircumcised) groups, were analyzed using HPV linear array. Adjusted LR-HPV prevalence rate ratio (aPPR) and Poisson mean ratio (aPMR) of number of LR-HPV genotypes were estimated using log-Poisson regression, controlling for background characteristics, sexual behaviour, and HIV and HSV-2 statuses.

RESULTS:

Compared to controls, LR-HPV prevalence and mean number of genotypes were significantly lower among the intervention group ((8.5% versus 15.8%; aPRR: 0.54, P < .001) and (0.33 versus 0.18; aPMR: 0.54, P < .001), resp.). Mean number of LR-HPV genotypes increased with number of lifetime sexual partners and decreased with education level and consistent condom use.

CONCLUSIONS:

This study shows a reduction in LR-HPV infection among circumcised men.

PMID:
21584275
[PubMed - indexed for MEDLINE]
PMCID:
PMC3092496
Free PMC Article

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