Biol Psychiatry. 1990 Apr 1;27(7):741-6.

Naltrexone attenuates self-injurious behavior in mentally retarded subjects.

Kars H, Broekema W, Glaudemans-van Gelderen I, Verhoeven WM, van Ree JM.

Source

Institute for Mental Retardation, Eemeroord, Baarn, The Netherlands.

Abstract

The effect of naltrexone on the frequency of self-injurious behavior (SIB) was investigated in 6 male subjects with profound mental retardation. Following a double-blind placebo-controlled crossover design, naltrexone was administered in a dose of 50 mg once daily for 3 consecutive weeks. In 2 of 5 subjects, a significant decrease of SIB frequency could be demonstrated, and in 1, a tendency to a reduction was found. No effect on duration of restrain time was found in 3 subjects. These data suggest that disturbances of the endogenous opioid systems may be involved in the pathophysiology of SIB of certain patients.

PMID:: 2158355; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Elsevier Science

Molecular Biology Databases

NALTREXONE - HSDB

Supplemental Content

Save items

Related citations in PubMed

An orally administered opiate blocker, naltrexone, attenuates self-injurious behavior. [Am J Ment Retard. 1990]
An orally administered opiate blocker, naltrexone, attenuates self-injurious behavior.
Sandman CA, Barron JL, Colman H. Am J Ment Retard. 1990 Jul; 95(1):93-102.
Failure of naltrexone hydrochloride to reduce self-injurious and autistic behavior in mentally retarded adults. Double-blind placebo-controlled studies. [Arch Gen Psychiatry. 1995]
Failure of naltrexone hydrochloride to reduce self-injurious and autistic behavior in mentally retarded adults. Double-blind placebo-controlled studies.
Willemsen-Swinkels SH, Buitelaar JK, Nijhof GJ, van England H. Arch Gen Psychiatry. 1995 Sep; 52(9):766-73.
A case report of naltrexone treatment of self-injury and social withdrawal in autism. [J Autism Dev Disord. 1990]
A case report of naltrexone treatment of self-injury and social withdrawal in autism.
Walters AS, Barrett RP, Feinstein C, Mercurio A, Hole WT. J Autism Dev Disord. 1990 Jun; 20(2):169-76.
Review Self-injurious behavior: a review of the behavior and biology of self-mutilation. [Am J Psychiatry. 1991]
Review Self-injurious behavior: a review of the behavior and biology of self-mutilation.
Winchel RM, Stanley M. Am J Psychiatry. 1991 Mar; 148(3):306-17.
Review Self-injurious behavior and the efficacy of naltrexone treatment: a quantitative synthesis. [Ment Retard Dev Disabil Res Re...]
Review Self-injurious behavior and the efficacy of naltrexone treatment: a quantitative synthesis.
Symons FJ, Thompson A, Rodriguez MC. Ment Retard Dev Disabil Res Rev. 2004; 10(3):193-200.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.

Recent activity

Clear Turn Off Turn On

Naltrexone attenuates self-injurious behavior in mentally retarded subjects.
Naltrexone attenuates self-injurious behavior in mentally retarded subjects.
Biol Psychiatry. 1990 Apr 1 ;27(7):741-6.

PubMed
4-[2-(1-Acetyl-2-oxopropyl-idene)-hydrazino]-N-(pyrimidin-2-yl)benzene-sulfonami...
4-[2-(1-Acetyl-2-oxopropyl-idene)-hydrazino]-N-(pyrimidin-2-yl)benzene-sulfonamide.
Acta Crystallogr Sect E Struct Rep Online. 2009 May 23 ;65(Pt 6):o1397.

PubMed
Parvovirus B19-associated hemophagocytic syndrome.
Parvovirus B19-associated hemophagocytic syndrome.
Arch Intern Med. 1990 Apr ;150(4):897-9.

PubMed
(2S,4aR,6aR,7R,9S,10aS,10bR)-7-Carb-oxy-2-(3-fur-yl)-6a,10b-dimethyl-4,10-dioxop...
(2S,4aR,6aR,7R,9S,10aS,10bR)-7-Carb-oxy-2-(3-fur-yl)-6a,10b-dimethyl-4,10-dioxoperhydro-benzo[f]isochromen-9-yl acetate.
Acta Crystallogr Sect E Struct Rep Online. 2009 Feb 6 ;65(Pt 3):o471-2.

PubMed
Bis{(E)-3-[(diethyl-methyl-ammonio)meth-yl]-N-[3-(N,N-dimethyl-sulfamo-yl)-1-met...
Bis{(E)-3-[(diethyl-methyl-ammonio)meth-yl]-N-[3-(N,N-dimethyl-sulfamo-yl)-1-methyl-pyridin-4-yl-idene]-4-methoxy-anilinium} tetra-iodide penta-hydrate.
Acta Crystallogr Sect E Struct Rep Online. 2009 Jan 10 ;65(Pt 2):o283-4.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Naltrexone attenuates self-injurious behavior in mentally retarded subjects.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information