Trends Biochem Sci. 1990 Mar;15(3):108-12.

Mechanism and evolution of the uncoupling protein of brown adipose tissue.

Source

Institut für Physikalische Biochemie, Universität München, FRG.

Abstract

The uncoupling protein found in mitochondria from thermogenic brown adipose tissue is structurally very similar to two other mitochondrial carrier proteins transporting ADP/ATP and phosphate, respectively. Similarities are also seen with the mechanism of these carriers, which are part of a family of H+/OH(-)-substrate anion co-transporters, further strengthening the evidence that the uncoupling protein has evolved from this family of mitochondrial carrier proteins.

PMID:: 2158156; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Research Materials

online strain list - StrainInfo

Supplemental Content

Save items

Related citations in PubMed

Review The mitochondrial uncoupling protein: structural and genetic studies. [Prog Nucleic Acid Res Mol Biol...]
Review The mitochondrial uncoupling protein: structural and genetic studies.
Ricquier D, Bouillaud F. Prog Nucleic Acid Res Mol Biol. 1997; 56:83-108.
Sequence of the bovine mitochondrial phosphate carrier protein: structural relationship to ADP/ATP translocase and the brown fat mitochondria uncoupling protein. [EMBO J. 1987]
Sequence of the bovine mitochondrial phosphate carrier protein: structural relationship to ADP/ATP translocase and the brown fat mitochondria uncoupling protein.
Runswick MJ, Powell SJ, Nyren P, Walker JE. EMBO J. 1987 May; 6(5):1367-73.
Review The uncoupling protein UCP: a membraneous mitochondrial ion carrier exclusively expressed in brown adipose tissue. [Int J Biochem. 1991]
Review The uncoupling protein UCP: a membraneous mitochondrial ion carrier exclusively expressed in brown adipose tissue.
Klaus S, Casteilla L, Bouillaud F, Ricquier D. Int J Biochem. 1991; 23(9):791-801.
Review Structure and function of the uncoupling protein from brown adipose tissue. [Biochim Biophys Acta. 1999]
Review Structure and function of the uncoupling protein from brown adipose tissue.
Klingenberg M, Huang SG. Biochim Biophys Acta. 1999 Jan 8; 1415(2):271-96.
Review Homologues of the uncoupling protein from brown adipose tissue (UCP1): UCP2, UCP3, BMCP1 and UCP4. [Biochim Biophys Acta. 2001]
Review Homologues of the uncoupling protein from brown adipose tissue (UCP1): UCP2, UCP3, BMCP1 and UCP4.
Bouillaud F, Couplan E, Pecqueur C, Ricquier D. Biochim Biophys Acta. 2001 Mar 1; 1504(1):107-19.

See reviews... See all...

Cited by 19 PubMed Central articles

The plant mitochondrial carrier family: functional and evolutionary aspects. [Front Plant Sci. 2012]
The plant mitochondrial carrier family: functional and evolutionary aspects.
Haferkamp I, Schmitz-Esser S. Front Plant Sci. 2012; 3:2. Epub 2012 Jan 18.
The evolutionary trajectory of mitochondrial carrier family during metazoan evolution. [BMC Evol Biol. 2010]
The evolutionary trajectory of mitochondrial carrier family during metazoan evolution.
Gong M, Li J, Wang M, Wang J, Zen K, Zhang CY. BMC Evol Biol. 2010 Sep 16; 10:282. Epub 2010 Sep 16.
Deletion of inducible nitric-oxide synthase in leptin-deficient mice improves brown adipose tissue function. [PLoS One. 2010]
Deletion of inducible nitric-oxide synthase in leptin-deficient mice improves brown adipose tissue function.
Becerril S, Rodríguez A, Catalán V, Sáinz N, Ramírez B, Collantes M, Peñuelas I, Gómez-Ambrosi J, Frühbeck G. PLoS One. 2010 Jun 4; 5(6):e10962. Epub 2010 Jun 4.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Mechanism and evolution of the uncoupling protein of brown adipose tissue.
Mechanism and evolution of the uncoupling protein of brown adipose tissue.
Trends Biochem Sci. 1990 Mar ;15(3):108-12.

PubMed
Poly[potassium-μ-2-[2-(carboxymethyl)phenyl]acetato].
Poly[potassium-μ-2-[2-(carboxymethyl)phenyl]acetato].
Acta Crystallogr Sect E Struct Rep Online. 2008 Nov 29 ;64(Pt 12):m1626.

PubMed
Evaluation of homology modeling of HIV protease.
Evaluation of homology modeling of HIV protease.
Proteins. 1990 ;7(2):172-84.

PubMed
Sodium 2-mercaptoethanesulfonate monohydrate (coenzyme M sodium salt monohydrate...
Sodium 2-mercaptoethanesulfonate monohydrate (coenzyme M sodium salt monohydrate).
Acta Crystallogr Sect E Struct Rep Online. 2008 Oct 31 ;64(Pt 11):m1476-7.

PubMed
Osteoporosis and the metabolites of vitamin D.
Osteoporosis and the metabolites of vitamin D.
Metabolism. 1990 Apr ;39(4 Suppl 1):3-9.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Mechanism and evolution of the uncoupling protein of brown adipose tissue.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Research Materials

Supplemental Content

Save items

Related citations in PubMed

Cited by 19 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information