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J Virol. 1990 May;64(5):2110-6.

Structure and function of the Epstein-Barr virus BZLF1 protein.

Author information

  • 1Ludwig Institute for Cancer Research, St. Mary's Hospital Medical School, London, England.

Abstract

Five DNA-binding sites for the Epstein-Barr virus BZLF1 protein have been identified within three of the early viral promoters, and four of these binding sites contain a consensus AP-1 site. The part of the BZLF1 protein required for sequence-specific DNA binding to one of these AP-1-like sites was identified by deletion mapping. Site-directed mutagenesis of this DNA target suggests that BZLF1 may work partly by overcoming a cellular repressor of viral transcription.

PMID:
2157874
[PubMed - indexed for MEDLINE]
PMCID:
PMC249368
Free PMC Article
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