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Learn Mem. 2011 May 16;18(6):367-70. doi: 10.1101/lm.2097411. Print 2011 Jun.

Post-training intrahippocampal inhibition of class I histone deacetylases enhances long-term object-location memory.

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  • 1Neuroscience Graduate Group, Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.


Long-term memory formation involves covalent modification of the histone proteins that package DNA. Reducing histone acetylation by mutating histone acetyltransferases impairs long-term memory, and enhancing histone acetylation by inhibiting histone deacetylases (HDACs) improves long-term memory. Previous studies using HDAC inhibitors to enhance long-term memory have focused on the fear-conditioning task using broad-spectrum HDAC inhibitors. We have found that post-training intrahippocampal administration of the broad-spectrum HDAC inhibitor trichostatin A (TSA) or the class I HDAC-selective inhibitor MS275 enhances long-term object-location memory, supporting a role for class I HDACs in the enhancement of hippocampus-dependent memory induced by HDAC inhibition.

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