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Biophys J. 2011 May 18;100(10):L56-8. doi: 10.1016/j.bpj.2011.04.021.

Chromosomal position effects are linked to sir2-mediated variation in transcriptional burst size.

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  • 1Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada.


Gene expression noise varies with genomic position and is a driving force in the evolution of chromosome organization. Nevertheless, position effects remain poorly characterized. Here, we present a systematic analysis of chromosomal position effects by characterizing single-cell gene expression from euchromatic positions spanning the length of a eukaryotic chromosome. We demonstrate that position affects gene expression by modulating the size of transcriptional bursts, rather than their frequency, and that the histone deacetylase Sir2 plays a role in this process across the chromosome.

Copyright © 2011 Biophysical Society. Published by Elsevier Inc. All rights reserved.

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