Brain Res. 1990 Feb 26;510(1):158-60.

D-cycloserine acts as a partial agonist at the glycine modulatory site of the NMDA receptor expressed in Xenopus oocytes.

Watson GB, Bolanowski MA, Baganoff MP, Deppeler CL, Lanthorn TH.

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CNS Diseases Research, G.D. Searle & Company St. Louis, MO 63198.

Abstract

In the Xenopus oocyte preparation, D-cycloserine (DCS) had the profile of a partial agonist at the glycine modulatory site of the NMDA receptor. Maximal NMDA responses in the presence of DCS were only 40-50% of those in the presence of glycine. Glycine and D-serine were agonists at this site. The actions of DCS were competitively antagonized by HA-966, a known glycine antagonist.

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Anticonvulsant effects of the glycine/NMDA receptor ligands D-cycloserine and D-serine but not R-(+)-HA-966 in amygdala-kindled rats. [Br J Pharmacol. 1994]
Anticonvulsant effects of the glycine/NMDA receptor ligands D-cycloserine and D-serine but not R-(+)-HA-966 in amygdala-kindled rats.
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Singh L, Donald AE, Foster AC, Hutson PH, Iversen LL, Iversen SD, Kemp JA, Leeson PD, Marshall GR, Oles RJ. Proc Natl Acad Sci U S A. 1990 Jan; 87(1):347-51.
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Glycine decreases desensitization of N-methyl-D-aspartate (NMDA) receptors expressed in Xenopus oocytes and is required for NMDA responses.
Lerma J, Zukin RS, Bennett MV. Proc Natl Acad Sci U S A. 1990 Mar; 87(6):2354-8.
Review [The glycine receptor--the normal, pathological and therapeutic implications]. [Rev Med Chir Soc Med Nat Iasi....]
Review [The glycine receptor--the normal, pathological and therapeutic implications].
Nechifor M. Rev Med Chir Soc Med Nat Iasi. 1990 Jan-Mar; 94(1):223-4.

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D-cycloserine acts as a partial agonist at the glycine modulatory site of the NMDA receptor expressed in Xenopus oocytes.

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