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PLoS One. 2011 May 9;6(5):e17446. doi: 10.1371/journal.pone.0017446.

Polyamide-scorpion cyclam lexitropsins selectively bind AT-rich DNA independently of the nature of the coordinated metal.

Author information

  • 1School of Chemistry, University of Sydney, Sydney, New South Wales, Australia.

Abstract

Cyclam was attached to 1-, 2- and 3-pyrrole lexitropsins for the first time through a synthetically facile copper-catalyzed "click" reaction. The corresponding copper and zinc complexes were synthesized and characterized. The ligand and its complexes bound AT-rich DNA selectively over GC-rich DNA, and the thermodynamic profile of the binding was evaluated by isothermal titration calorimetry. The metal, encapsulated in a scorpion azamacrocyclic complex, did not affect the binding, which was dominated by the organic tail.

PMID:
21573061
[PubMed - indexed for MEDLINE]
PMCID:
PMC3090394
Free PMC Article

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