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Indian J Pharmacol. 2011 Apr;43(2):214-5. doi: 10.4103/0253-7613.77378.

Chronic phenytoin therapy-induced vecuronium resistance.

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  • 1Department of Pharmacology, Institute of Postgraduate Medical Education & Research, Kolkata, India.


This case report highlights a clinically significant pharmacokinetic drug interaction between phenytoin, a widely used anticonvulsant and vecuronium, a non-depolarizing neuromuscular blocker which led to vecuronium resistance.


Drug interaction; phenytoin; resistance; vecuronium

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