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Indian J Pharmacol. 2011 Apr;43(2):197-9. doi: 10.4103/0253-7613.77368.

Anticataleptic and antiepileptic activity of ethanolic extract of leaves of Mucuna pruriens: A study on role of dopaminergic system in epilepsy in albino rats.

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  • 1Department of Pharmacology, University Department of Pharmaceutical Sciences, Bhubaneswar-751 004, Orissa, India.

Abstract

OBJECTIVE:

To assess the anticataleptic and antiepileptic activity of leaves of Mucuna pruriens in albino rats.

MATERIALS AND METHODS:

Haloperidol-induced catalepsy (HIC), maximum electro-shock (MES) method, pilocarpine-induced Status epilepticus (PISE) and single-dose effect of M. pruriens were employed.

RESULTS:

M. pruriens (100 mg/kg) had significant anticataleptic and antiepileptic activity in HIC, MES, and PISE.

CONCLUSIONS:

M. pruriens extract has the potential to be an anticataleptic and antiepileptic drug. Dopamine and 5-HT may have a role in such activity.

KEYWORDS:

Catalepsy; Mucuna pruriens; dopamine; epilepsy

PMID:
21572658
[PubMed]
PMCID:
PMC3081462
Free PMC Article
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