Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Indian J Pharmacol. 2011 Apr;43(2):113-20. doi: 10.4103/0253-7613.77335.

Vitamin D as a promising anticancer agent.

Author information

  • Department of Microbiology, Kanak Manjari Institute of Pharmaceutical Sciences, Rourkela, India.

Abstract

Presence of vitamin D receptors in noncalcemic tissues and subsequent identification of its involvement in growth factor(s)-mediated cellular function suggested its probable beneficial role in genesis, progression and survival of cancerous growths. Data collected from both in vitro and in vivo studies are highly optimistic regarding its potential in prevention and regression of colorectal, prostate and breast cancers. The vitamin has been found to interfere with the transduction pathways of various growth factor(s)-activated receptors (receptor tyrosine kinases) thereby modulating transcription and alteration of genomic functions resulting in inhibition of cell proliferation and angiogenesis and facilitation of cell differentiation and apoptosis. It also increases the level of an endogenous protein - cystatin D, which possesses antitumor and antimetastatic property, by facilitation of the expression of the gene coding for it. Though not as a primary anticancer agent, this vitamin may be used for the prevention of cancer and included as an adjuvant in combination chemotherapy for the treatment of cancer.

KEYWORDS:

Angiogenesis; apoptosis; cancer; cell proliferation; vitamin D

PMID:
21572642
[PubMed]
PMCID:
PMC3081446
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Medknow Publications and Media Pvt Ltd Icon for PubMed Central
    Loading ...
    Write to the Help Desk