Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Craniovertebr Junction Spine. 2010 Jul;1(2):67-73. doi: 10.4103/0974-8237.77670.

Malignant cord compression: A critical appraisal of prognostic factors predicting functional outcome after surgical treatment.

Author information

  • 1Spinal Cord Injury Center, Heidelberg University Hospital, Germany.

Abstract

OBJECTIVES:

Advanced tumor disease and metastatic spinal cord compression (MSCC) are two entities with a high impact on patients' quality of life. However, prognostic factors on the outcome after primary decompressive surgery are less well-defined and not yet standardized. The aim of this review was to identify prognostic variables that predict functional or ambulatory outcomes in surgically treated patients with symptomatic MSCC.

MATERIALS AND METHODS:

We conducted MEDLINE database searches using relevant keywords in order to identify abstracts referring to prognostic factors on ambulatory outcomes in surgically treated MSCC patients. Details of all selected articles were assembled and the rates of ambulation were stratified.

RESULTS:

Evidence from five retrospective comparative trials and one observational prospective study summarizes different prognostic factors with a positive or negative influence on postoperative ambulatory status. Ambulatory patients maintaining ambulation status after decompression of the spinal cord constituted 62.1%. The overall rate of MSCC patients losing the ability to ambulate was 7.5% compared to 23.5 % who regained ambulation. Preoperative ambulation status, time to surgery, compression fracture and individual health status seem to be the most relevant prognostic factors for ambulatory outcome.

CONCLUSIONS:

There is a lack of standardized prognostic tools which allow predicting outcome in surgically treated patients. A quantitative score consisting of reliable prognostic tools is essential to predict loss and/or regain of ambulation and requires validation in future prospective clinical trials.

KEYWORDS:

Functional outcome; metastatic spinal cord compression; prognostic factors

PMID:
21572627
[PubMed]
PMCID:
PMC3075832
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Medknow Publications and Media Pvt Ltd Icon for PubMed Central
    Loading ...
    Write to the Help Desk