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Am J Psychiatry. 2011 Aug;168(8):848-52. doi: 10.1176/appi.ajp.2011.10091319. Epub 2011 May 15.

A 3p26-3p25 genetic linkage finding for DSM-IV major depression in heavy smoking families.

Author information

  • 1Department of Psychiatry, WashingtonUniversity School of Medicine, Saint Louis, MO 63110, USA. pergadim@psychiatry.wustl.edu

Abstract

OBJECTIVE:

The authors tested for genetic linkage of DSM-IV-diagnosed major depressive disorder in families that were ascertained for cigarette smoking.

METHOD:

Within a study that targeted families characterized by a history of smoking, analyses derived a subset of 91 Australian families with two or more offspring with a history of DSM-IV major depressive disorder (affected sibling pairs, N=187) and 25 Finnish families (affected sibling pairs, N=33). Within this affected sibling pairs design, the authors conducted nonparametric linkage analysis.

RESULTS:

In the Australian heavy smoking families, the authors found a genome-wide significant multipoint LOD score of 4.14 for major depressive disorder on chromosome 3 at 24.9 cM (3p26-3p25).

CONCLUSIONS:

Genome-wide significant linkage was detected for major depressive disorder on chromosome 3p in a sample ascertained for smoking. A linkage peak at this location was also observed in an independent study of major depressive disorder.

PMID:
21572167
[PubMed - indexed for MEDLINE]
PMCID:
PMC3433250
Free PMC Article

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