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Invest Ophthalmol Vis Sci. 2011 Aug 3;52(9):6168-73. doi: 10.1167/iovs.11-7321.

Comparison of film and digital fundus photographs in eyes of individuals with diabetes mellitus.

Collaborators (429)

Ramasamy K, Munch IC, Larsen M, Olson JA, Kim NM, Uwaydat SH, Goldenberg DT, Kunimoto DY, Quinlan EJ, Gaitan JR, Jamal KN, Mehta S, Goldenberg DT, Kunimoto DY, Quinlan EJ, Gaitan JR, Jamal KN, Mehta S, Goldenberg DT, Kunimoto DY, Quinlan EJ, Gaitan JR, Jamal KN, Mehta S, Leong CJ, Daniels SA, Ray SK, Ting TD, Ranchod TM, Leong CJ, Daniels SA, Ray SK, Ting TD, Ranchod TM, Castellarin AA, Pieramici DJ, Nasir MA, Castellarin AA, Pieramici DJ, Nasir MA, Castellarin AA, Pieramici DJ, Nasir MA, Fan JT, Rauser ME, Suthar MB, Fan JT, Rauser ME, Suthar MB, Liao DS, Tabandeh H, Novack RL, Diddie KR, Nuthi AS, Chan CK, Lin SG, Kuppermann BD, Lu SY, Quiroz-Mercado H, Chaudhry NA, Chaudhry NA, Mathura JR, Plous OZ, Mestrezat WJ, Friedman SM, Friedman SM, Friedman SM, Friedman SM, Burgess SK, Niffenegger JH, Wong KL, Lehr JT, Moinfar N, Friedman SM, Ghuman AT, Sharma AG, Wing G, Walker JP, Raskauskas PA, Niffenegger JH, Wong KL, Niffenegger JH, Wong KL, Niffenegger JH, Wong KL, Niffenegger JH, Wong KL, Halperin LS, Dhalla MS, Thompson WS, Levy M, Chen M, Torres W, Ganiban GJ, Vaishnav HD, Chalam KV, Grover S, Gupta SK, Cribbs BE, Hubbard GB, Yan J, Sharma A, Stallman JB, Miller JJ, Rivellese MJ, Jacobson MS, Stoltz RA, Lampert SI, Koh SS, Vanderveldt SL, Marcus DM, Singh H, Drouilhet JH, Scott MH, Saggau DD, Nielsen JS, Sohn JH, Alliman KJ, Saggau DD, Nielsen JS, Sohn JH, Alliman KJ, Saggau DD, Nielsen JS, Sohn JH, Alliman KJ, Pollack JS, Pollack JS, MacCumber MW, Maker MP, Sheth VS, Lyon AT, Gill MK, Mirza RG, Packo KH, MacCumber MW, Merrill PT, Ravage ZB, Packo KH, MacCumber MW, Merrill PT, Ravage ZB, Chau FY, Lim JI, Ulanski LJ, Leiderman YI, Lazarus HS, Maturi RK, Maturi RK, Poulose AK, Sabates FN, Cassell MA, Sabates NR, Symons RC, Baker CW, Tilford RH, Kitchens JW, Isernhagen RD, Stone TW, Wood WJ, Andreoli CM, Schlossman DK, Sharuk GS, Sun JK, Aiello LP, Silva PS, Arrigg PG, Shah ST, Murtha TJ, Andreoli CM, Schlossman DK, Sharuk GS, Sun JK, Aiello LP, Silva PS, Arrigg PG, Shah ST, Murtha TJ, Heier JS, Cleary TS, Topping TM, Elman MJ, Elman MJ, Elman MJ, Benner JD, Butler JW, Ahmad ZM, Scott AW, Do DV, Duh EJ, Scholl HP, Bressler NM, Solomon SD, Bressler S, Gao H, Edwards PA, Desai U, Gao H, Edwards PA, Desai U, Gao H, Edwards PA, Desai U, Westhouse SJ, Aaberg TM, Garber FW, Zheutlin JD, Glazer LC, Bhavsar A, Emerson GG, Jones JM, Emerson MV, Koozekanani D, Montezuma SR, Rosenthal WN, Smith BT, Blinder KJ, Apte RS, Smith BT, Blinder KJ, Apte RS, Antoszyk AN, Browning D, Brown JC, Antoszyk AN, Browning D, Brown JC, Antoszyk AN, Browning D, Brown JC, Antoszyk AN, Browning D, Brown JC, Antoszyk AN, Browning D, Brown JC, Sanders JB, Houghton OM, Chavala SH, Garg S, Meredith TA, Richards CP, Greven CM, Slusher MM, Kurup SK, Chruscicki DA, Margalit E, Hejkal TW, Chace R, Ie D, Lipkowitz JL, Shah KB, Zarbin MA, Roy MS, Bhagat N, King JS, Raut R, Rosberger DF, Vaidya NN, Levinson DH, Tsui I, Mian UK, Pahk PJ, Ginsburg RN, Teich SA, Jermak CM, Koreishi FM, Khan MA, Lee PJ, Rutledge BK, Hampton GR, Brown JS, Ponce EA, Gentile RC, DiLoreto DA, Kleinman DM, Chung MM, Ramchandran RS, Tang J, Wilker SC, Huang SS, Letson AD, Cebulla CM, Davidorf FH, Christoforidis JB, Kurz PA, Chang S, Miller DG, Schartman JP, Coney JM, Singerman LJ, Novak MA, Miller DG, Schartman JP, Coney JM, Singerman LJ, Novak MA, Miller DG, Schartman JP, Coney JM, Singerman LJ, Novak MA, Tang J, Wilker SC, Huang SS, Tang J, Bradford RH, Leonard RE, Kingsley RM, Fransen SR, Lauer AK, Flaxel CJ, Francis PJ, Bailey ST, Ma C, Handelman IL, Peters MA, Lee MS, Dreyer RF, Pavlica MR, Bowie EM, Scott IU, Neely KA, Doft BH, Liu JC, Olsen KR, Conrad PW, Rath PP, Bergren RL, Doft BH, Liu JC, Olsen KR, Conrad PW, Rath PP, Bergren RL, Brucker AJ, Estafanous MF, Kaufman SR, Smith CW, Woodcome HA, Fishburne BC, Gross JG, Magee MA, Fishburne BC, Gross JG, Magee MA, Wells JA, Clark WL, Kylstra JA, Patel NM, Abraham P, Chaum E, Googe JM, Anderson NG, Perkins SL, McMillan TA, Googe JM, Anderson NG, Perkins SL, McMillan TA, Googe JM, Anderson NG, Perkins SL, McMillan TA, Couch DA, Cummings HL, Gunn JM, Recchia FM, Kim SJ, Carvounis PE, Garcia CA, Pons ME, Garcia CA, Pons ME, Garcia CA, Pons ME, Bell DJ, Singer MA, Willis AW, Lambert HM, Khawly JA, Willis AW, Lambert HM, Khawly JA, Brown DM, Chen E, Major JC, Benz MS, Fish RH, Wong TP, Berger BB, Berger BB, Janzen GP, Lee SY, Patel SS, Mein CE, Chica MA, Holy SE, Davis GH, Fish GE, Wang RC, Shami M, Patel NR, Diaz-Rohena R, Gonzalez VH, Patel NR, Diaz-Rohena R, Gonzalez VH, Lauer AK, Flaxel CJ, Francis PJ, Bailey ST, Ma C, Handelman IL, Peters MA, Lee MS, Dreyer RF, Vemulakonda GA, Kinyoun JL, Weinberg DV, Han DP, Kim JE, Stepien KE, Connor TB, Wirostko WJ, Blodi BA, Gottlieb J, Altaweel MM, Ip MS.

Abstract

PURPOSE:

To compare grading of diabetic retinopathy (DR) and diabetic macular edema (DME) from stereoscopic film versus stereoscopic digital photographs obtained from a subset of Diabetic Retinopathy Clinical Research Network (DRCR.net) participants.

METHODS:

In this photographic media comparison study, digital and film images were obtained at a single study visit from some of the subjects enrolled in active DRCR.net clinical study protocols. Digital camera systems and digital and film photographers were certified to obtain images according to standard procedures. Images were graded for DR severity and DME in a masked fashion by Fundus Photograph Reading Center (Madison, WI) graders. Agreement between gradings was assessed by calculating the percentage of agreement and κ statistics.

RESULTS:

Images obtained with both film and digital media were submitted for 155 eyes of 96 study participants. On a nine-step Early Treatment Diabetic Retinopathy study DR severity scale, grading agreed exactly in 74%, and was within one step of agreement in 93%, with a weighted κ statistic of 0.82 (95% confidence interval [CI], 0.71-0.92). On a nine-step DME severity scale and three-step clinically significant macular edema (CSME) scale, grading agreed exactly in 39% and 88%, respectively, and within one step in 70% and 92% (weighted κ statistic, 0.44 [95% Cl, 0.34-0.54] and 0.72 [95% Cl, 0.55-0.90], respectively).

CONCLUSIONS:

Among clinical sites participating in the DRCR.net, agreement between film and digital images was substantial to almost perfect for DR severity level and moderate to substantial for DME and CSME severity levels, respectively. Replacement of film fundus images with digital images for DR severity level should not adversely affect clinical trial quality. (ClinicalTrials.gov numbers, NCT00367133, NCT00369486, NCT00444600, NCT00445003, NCT00709319.)

PMID:
21571677
[PubMed - indexed for MEDLINE]
PMCID:
PMC3176025
Free PMC Article
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