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Nature. 1990 Mar 29;344(6265):395-400.

Signal transduction in bacteria.

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  • 1Department of Molecular Biology, Princeton University, New Jersey 08544.


Cells display a remarkable ability to respond to small fluctuations in their surroundings. In simple microbial systems, information from sensory receptors feeds into a circuitry of regulatory proteins that transfer high energy phosphoryl groups from histidine to aspartate side chains. This phosphotransfer network couples environmental signals to an array of response elements that control cell motility and regulate gene expression.

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