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    Mol Microbiol. 1990 Jan;4(1):129-35.

    Two cyclic AMP-regulated genes from Dictyostelium discoideum encode homologous proteins.

    Ramji DP, Richards AJ, Jagger P, Bleasby A, Hames BD.

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    Department of Biochemistry, University of Leeds, UK.

    Abstract

    Expression of the 7E and 2C genes late in Dictyostelium development ceases upon cell disaggregation but, in contrast to many other genes we have studied, expression is fully restored by exogenous cAMP (A. J. Richards et al., submitted). The 7E and 2C genes encode polypeptides of similar size (9220 and 10573 Daltons, respectively), each of which contains an unusually high proportion of serine plus glycine residues (41% and 59%, respectively). Each protein possesses a relatively serine-rich N-terminus and glycine-rich C-terminus and contains the conserved sequence S(X)SSS(X2)SS(X)SS(X2)SFGS. These data suggest that genes 7E and 2C may have arisen by duplication of a common ancestor. Computer analysis indicates that both gene products are probably intracellular structural proteins that form extended coil structures.

    PMID:
    2157129
    [PubMed - indexed for MEDLINE]

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