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    FEBS Lett. 2011 Jun 23;585(12):1915-22. Epub 2011 May 9.

    c-Jun/AP-1 transcription factor regulates laminin-1-induced neurite outgrowth in human bone marrow mesenchymal stem cells: role of multiple signaling pathways.

    Mruthyunjaya S, Rumma M, Ravibhushan G, Anjali S, Padma S.

    Source

    National Centre for Cell Science, Ganeshkhind, Pune, India.

    Abstract

    In this study, we demonstrated that laminin-1 (LM-1) induces neurite outgrowth and enhances the expression of neurofilament-L and MAP2 in human bone marrow mesenchymal stem cells (MSCs). The c-Jun transcription factor was strongly activated by LM-1 during neurite induction. Suppression of c-Jun inhibited the expression of the c-Jun target genes α6 integrin and neurofilament-L, resulting in the loss of neurite outgrowth. Additionally, we found that the LM-1-α6 integrin interaction stimulated phosphorylation of FAK, leading to the activation of JNK and Akt. Pharmacological inhibition of these pathways blocked c-Jun activation and neurite outgrowth. Collectively, our findings suggest that c-Jun/AP-1 activity mediated by JNK, PI3K/Akt and ERK pathways is required for LM-1-induced neurite outgrowth in human bone marrow MSCs.

    Copyright © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

    PMID:
    21570970
    [PubMed - indexed for MEDLINE]

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