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Drug Discov Today. 2011 Jul;16(13-14):626-35. doi: 10.1016/j.drudis.2011.04.007. Epub 2011 May 5.

The impact of epigenomics on future drug design and new therapies.

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  • 1Cancer Biology and Epigenomics Program, Children's Memorial Research Center and Northwestern University's Feinberg School of Medicine, 2430N. Halsted St, Box 220, Chicago, IL, USA.

Abstract

The future of drug design and the development of new therapeutics will rely on our ability to unravel the complexities of the epigenome in normal and disease states. Proper epigenetic regulation is essential for normal differentiation in embryogenesis and development. Conversely, abnormal epigenetic regulation is a feature of complex diseases, including cancer, diabetes, heart disease and other pathologies. Epigenetic therapies hold promise for a wide range of biological applications, from cancer treatment to the establishment of induced pluripotent stem cells. The creation of more specific and effective epigenetic therapies, however, requires a more complete understanding of epigenomic landscapes. Here, we give a historical overview of the epigenomics field and how epigenetic modifications can affect embryo development and disease etiology. We also discuss the impact of current and future epigenetic drugs.

Copyright © 2011 Elsevier Ltd. All rights reserved.

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