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    Vaccine. 2011 Jun 24;29(29-30):4735-8. Epub 2011 May 12.

    Immunogenicity and safety of a pediatric dose virosomal hepatitis A vaccine in Thai HIV-infected children.

    Saksawad R, Likitnukul S, Warachit B, Hanvivatvong O, Poovorawan Y, Puripokai P.

    Source

    Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Rama 4 Road, Pratumwan, Bangkok 10330, Thailand.

    Abstract

    The immunogenicity and safety of a pediatric dose of a virosomal hepatitis A vaccine (Epaxal®) was evaluated in a group of 45 Thai children with human immunodeficiency virus (HIV) infection, age 2-16 years. Vaccines were administered at 0 and 6 months. Anti-HAV antibody titers were measured at baseline (before injection) 1 and 7 months after primary vaccination. The prevalence of HAV protective antibody in 45 Thai HIV-infected children was 13.6%. The seroprotection rate was 71% at 1 month and 100% at 7 months. The booster dose increased geometric mean concentration (GMC) from 106.5 mIU/ml to 3486.1 mIU/ml. Higher CD4 lymphocyte counts at enrollment was a predictive factor for HAV antibody response. Both doses of Epaxal® were well tolerated. These preliminary data suggest that a pediatric dose of Epaxal® is an effective hepatitis A vaccine for HIV-infected children and should be considered for implementation on a larger scale in the pediatric HIV population.

    Copyright © 2011 Elsevier Ltd. All rights reserved.

    PMID:
    21570433
    [PubMed - indexed for MEDLINE]

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