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Science. 2011 May 13;332(6031):852-5. doi: 10.1126/science.1202143.

Polarized notum activation at wounds inhibits Wnt function to promote planarian head regeneration.

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  • 1Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.

Abstract

Regeneration requires initiation of programs tailored to the identity of missing parts. Head-versus-tail regeneration in planarians presents a paradigm for study of this phenomenon. After injury, Wnt signaling promotes tail regeneration. We report that wounding elicits expression of the Wnt inhibitor notum preferentially at anterior-facing wounds. This expression asymmetry occurs at essentially any wound, even if the anterior pole is intact. Inhibition of notum with RNA interference (RNAi) causes regeneration of an anterior-facing tail instead of a head, and double-RNAi experiments indicate that notum inhibits Wnt signaling to promote head regeneration. notum expression is itself controlled by Wnt signaling, suggesting that regulation of feedback inhibition controls the binary head-tail regeneration outcome. We conclude that local detection of wound orientation with respect to tissue axes results in distinct signaling environments that initiate appropriate regeneration responses.

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PMID:
21566195
[PubMed - indexed for MEDLINE]
PMCID:
PMC3320723
Free PMC Article
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