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    Scand J Infect Dis. 2011 Oct;43(10):821-6. Epub 2011 May 12.

    Tenofovir-induced Fanconi syndrome and osteomalacia in two HIV-infected patients: role of intracellular tenofovir diphosphate levels and review of the literature.

    Haverkort ME, van der Spek BW, Lips P, Slieker WA, ter Heine R, Huitema AD, Bronsveld W.

    Source

    Department of Internal Medicine, Sionsberg Hospital, Dokkum. mehaverkort@hotmail.com

    Abstract

    We present 2 human immunodeficiency virus-infected patients with tenofovir disoproxil fumarate-induced Fanconi syndrome, leading to osteomalacia. Intracellular tenofovir diphosphate levels were measured in 1 patient and were found to be very high, with plasma tenofovir levels just slightly elevated. Fibroblast growth factor-23, a phosphaturic hormone, was decreased in both patients and is therefore unlikely to have a pathophysiological role in this pathology. The different potential factors contributing to the development of tenofovir-related kidney proximal tubular dysfunction are discussed and the data presented may help to further elucidate its pathogenesis.

    PMID:
    21563880
    [PubMed - indexed for MEDLINE]

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