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Lab Chip. 2011 Jun 21;11(12):2049-54. doi: 10.1039/c1lc20164f. Epub 2011 May 12.

On-chip magnetically actuated robot with ultrasonic vibration for single cell manipulations.

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  • 1Department of Mechanical Science and Engineering, Nagoya University, Nagoya, Japan. hagiwara@biorobotics.mech.nagoya-u.ac.jp


This paper presents an innovative driving method for an on-chip robot actuated by permanent magnets in a microfluidic chip. A piezoelectric ceramic is applied to induce ultrasonic vibration to the microfluidic chip and the high-frequency vibration reduces the effective friction on the MMT significantly. As a result, we achieved 1.1 micrometre positioning accuracy of the microrobot, which is 100 times higher accuracy than without vibration. The response speed is also improved and the microrobot can be actuated with a speed of 5.5 mm s(-1) in 3 degrees of freedom. The novelty of the ultrasonic vibration appears in the output force as well. Contrary to the reduction of friction on the microrobot, the output force increased twice as much by the ultrasonic vibration. Using this high accuracy, high speed, and high power microrobot, swine oocyte manipulations are presented in a microfluidic chip.

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