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Mater Res Soc Symp Proc. 2009 Jan 1;1209. pii: 1209-YY03-01.

Nanoengineering of Immune Cell Function.

Author information

  • 1Department of Biomedical Engineering, Columbia University, New York, NY 10027, U.S.A.

Abstract

T lymphocytes are a key regulatory component of the adaptive immune system. Understanding how the micro- and nano-scale details of the extracellular environment influence T cell activation may have wide impact on the use of T cells for therapeutic purposes. In this article, we examine how the micro- and nano-scale presentation of ligands to cell surface receptors, including microscale organization and nanoscale mobility, influences the activation of T cells. We extend these studies to include the role of cell-generated forces, and the rigidity of the microenvironment, on T cell activation. These approaches enable delivery of defined signals to T cells, a step toward understanding the cell-cell communication in the immune system, and developing micro/nano- and material- engineered systems for tailoring immune responses for adoptive T cell therapies.

PMID:
21562611
[PubMed]
PMCID:
PMC3090082
Free PMC Article

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