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Mol Biol Cell. 2011 Jul 1;22(13):2282-9. doi: 10.1091/mbc.E10-09-0766. Epub 2011 May 11.

Vimentin intermediate filaments modulate the motility of mitochondria.

Author information

  • 1Group of Cell Biology, Institute of Protein Research, Russian Academy of Sciences, Moscow 119988, Russia.

Abstract

Interactions with vimentin intermediate filaments (VimIFs) affect the motility, distribution, and anchorage of mitochondria. In cells lacking VimIFs or in which VimIF organization is disrupted, the motility of mitochondria is increased relative to control cells that express normal VimIF networks. Expression of wild-type VimIF in vimentin-null cells causes mitochondrial motility to return to normal (slower) rates. In contrast, expressing vimentin with mutations in the mid-region of the N-terminal non-α-helical domain (deletions of residues 41-96 or 45-70, or substitution of Pro-57 with Arg) did not inhibit mitochondrial motility even though these mutants retain their ability to assemble into VimIFs in vivo. It was also found that a vimentin peptide consisting of residues 41-94 localizes to mitochondria. Taken together, these data suggest that VimIFs bind directly or indirectly to mitochondria and anchor them within the cytoplasm.

PMID:
21562225
[PubMed - indexed for MEDLINE]
PMCID:
PMC3128530
Free PMC Article

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