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Biomed Opt Express. 2011 Apr 27;2(5):1359-65. doi: 10.1364/BOE.2.001359.

Combined photoacoustic microscopy and optical coherence tomography can measure metabolic rate of oxygen.


We proposed to measure the metabolic rate of oxygen (MRO(2)) in small animals in vivo using a multimodal imaging system that combines laser-scanning optical-resolution photoacoustic microscopy (LSOR-PAM) and spectral-domain optical coherence tomography (SD-OCT). We first tested the capability of the multimodal system to measure flow rate in a phantom made of two capillary tubes of different diameters. We then demonstrated the capability of measuring MRO(2) by imaging two parallel vessels selected from the ear of a Swiss Webster mouse. The hemoglobin oxygen saturation (sO(2)) and the vessel diameter were measured by the LSOR-PAM and the blood flow velocity was measured by the SD-OCT, from which blood flow rate and MRO(2) were further calculated. The measured blood flow rates in the two vessels agreed with each other.


(110.5120) Photoacoustic imaging; (170.2655) Functional monitoring and imaging; (170.4500) Optical coherence tomography

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