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Biomed Opt Express. 2011 Apr 7;2(5):1121-34. doi: 10.1364/BOE.2.001121.

Fiber optic microendoscopy for preclinical study of bacterial infection dynamics.

Abstract

We explore the use of fiber optic microendoscopy to image and quantify bacterial infection in the skin and lungs using an animal model. The contact probe fiber bundle fluorescence microendoscope has a 4 µm resolution, a 750 µm field of view, and a 1 mm outer diameter. Subcutaneous and intra-tracheal infections of fluorescent Mycobacterium bovis Bacillus Calmette-Guérin (BCG) bacteria were detected in situ from inocula down to 10(4) and 10(7) colony forming units, respectively.

KEYWORDS:

(060.2350) Fiber optics imaging; (110.0110) Imaging systems; (170.2150) Endoscopic imaging; (170.3880) Medical and biological imaging

PMID:
21559125
[PubMed]
PMCID:
PMC3087570
Free PMC Article

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