Ileal interposition attenuates the satiety responses evoked by cholecystokinin-8 and -33

Peptides. 2011 Jun;32(6):1296-302. doi: 10.1016/j.peptides.2011.04.023. Epub 2011 Apr 30.

Abstract

One of the possible mechanisms by which the weight-reducing surgical procedure ileal interposition (II) works is by increasing circulating levels of lower gut peptides that reduce food intake, such as glucagon like peptide-1 and peptide YY. However, since this surgery involves both lower and upper gut segments, we tested the hypothesis that II alters the satiety responses evoked by the classic upper gut peptide cholecystokinin (CCK). To test this hypothesis, we determined meal size (MS), intermeal interval (IMI) and satiety ratio (SR) evoked by CCK-8 and -33 (0, 1, 3, 5nmol/kg, i.p.) in two groups of rats, II and sham-operated. CCK-8 and -33 reduced MS more in the sham group than in the II group; CCK-33 prolonged IMI in the sham group and increased SR in both groups. Reduction of cumulative food intake by CCK-8 in II rats was blocked by devazepide, a CCK(1) receptor antagonist. In addition, as previously reported, we found that II resulted in a slight reduction in body weight compared to sham-operated rats. Based on these observations, we conclude that ileal interposition attenuates the satiety responses of CCK. Therefore, it is unlikely that this peptide plays a significant role in reduction of body weight by this surgery.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Body Weight / drug effects
  • Cholecystokinin / administration & dosage*
  • Devazepide / pharmacology
  • Dose-Response Relationship, Drug
  • Eating / drug effects*
  • Eating / physiology
  • Eating / psychology
  • Feeding Behavior / drug effects*
  • Feeding Behavior / physiology
  • Feeding Behavior / psychology
  • Ileum / surgery
  • Jejunoileal Bypass / methods*
  • Jejunum / surgery
  • Male
  • Peptide Fragments / administration & dosage*
  • Rats
  • Rats, Wistar
  • Receptors, Cholecystokinin / antagonists & inhibitors*
  • Receptors, Cholecystokinin / metabolism
  • Satiety Response / drug effects*
  • Satiety Response / physiology

Substances

  • Peptide Fragments
  • Receptors, Cholecystokinin
  • cholecystokinin 8
  • Cholecystokinin
  • Devazepide