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J Surg Oncol. 2011 Sep;104(4):438-46. doi: 10.1002/jso.21969. Epub 2011 May 9.

Prognostic molecular biomarkers for cutaneous malignant melanoma.

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  • 1Department of Molecular Oncology, John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, California, USA.

Abstract

Molecular signatures of melanoma have propelled new approaches to early diagnosis, monitoring of treatment response, and targeted therapy. This review discusses messenger RNA (mRNA), genomic, and epigenomic melanoma biomarkers in blood and tissue specimens. The major focus is on tissue-based molecular assays to upstage sentinel lymph nodes (SLNs), and blood-based assays to detect melanoma progression by monitoring levels of circulating tumor cells (CTC) and circulating DNA.

Copyright © 2011 Wiley-Liss, Inc.

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