Chromosoma. 2011 Aug;120(4):399-407. doi: 10.1007/s00412-011-0321-1. Epub 2011 May 10.

Co-transcriptional architecture in a Y loop in Drosophila melanogaster.

Source

Department of Physiology, Development and Neuroscience, University of Cambridge, UK.

Abstract

The Y loops of Drosophila spermatocytes are formed by the expression of huge individual transcription units on the Y chromosome and their large size provides a unique system for the investigation of the organisation of transcription in intact nuclei. By labelling ribonucleo-protein (RNP) components, the loop chromatin and nascent transcripts in Y loop C, we reveal a highly structured organisation of RNP domains associated with nascent transcripts. We distinguish two types of RNP domain, a proximal domain that runs alongside the chromatin of loop C and a distal RNP domain that wraps around the proximal domain and the loop chromatin. The proximal domain is marked by the Pasilla protein, and separate distal subdomains are marked by the S5 antigen and Boule. We discuss the implications of this highly structured co-transcriptional architecture for the organisation of the process of transcription.

PMID:: 21556802; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

Research Support, Non-U.S. Gov't

MeSH Terms

Substances

Grant Support

Biotechnology and Biological Sciences Research Council/United Kingdom

LinkOut - more resources

Full Text Sources

Supplemental Content

Related citations

Association of RB97D, an RRM protein required for male fertility, with a Y chromosome lampbrush loop in Drosophila spermatocytes. [Chromosoma. 1996]
Association of RB97D, an RRM protein required for male fertility, with a Y chromosome lampbrush loop in Drosophila spermatocytes.
Heatwole VM, Haynes SR. Chromosoma. 1996 Dec; 105(5):285-92.
Association of SARFH (sarcoma-associated RNA-binding fly homolog) with regions of chromatin transcribed by RNA polymerase II. [Mol Cell Biol. 1995]
Association of SARFH (sarcoma-associated RNA-binding fly homolog) with regions of chromatin transcribed by RNA polymerase II.
Immanuel D, Zinszner H, Ron D. Mol Cell Biol. 1995 Aug; 15(8):4562-71.
Omega speckles - a novel class of nuclear speckles containing hnRNPs associated with noncoding hsr-omega RNA in Drosophila. [J Cell Sci. 2000]
Omega speckles - a novel class of nuclear speckles containing hnRNPs associated with noncoding hsr-omega RNA in Drosophila.
Prasanth KV, Rajendra TK, Lal AK, Lakhotia SC. J Cell Sci. 2000 Oct; 113 Pt 19:3485-97.
Review Chromatin mechanisms in Drosophila dosage compensation. [Prog Mol Subcell Biol. 2005]
Review Chromatin mechanisms in Drosophila dosage compensation.
Taipale M, Akhtar A. Prog Mol Subcell Biol. 2005; 38:123-49.
Review Multiple roles of the Y chromosome in the biology of Drosophila melanogaster. [ScientificWorldJournal. 2010]
Review Multiple roles of the Y chromosome in the biology of Drosophila melanogaster.
Piergentili R. ScientificWorldJournal. 2010 Sep 1; 10:1749-67. Epub 2010 Sep 1.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.

Recent activity

Clear Turn Off Turn On

Co-transcriptional architecture in a Y loop in Drosophila melanogaster.
Co-transcriptional architecture in a Y loop in Drosophila melanogaster.
Chromosoma. 2011 Aug ;120(4):399-407. doi: 10.1007/s00412-011-0321-1. Epub 2011 May 10 .

PubMed
Nucleosome positioning and nucleosome stacking: two faces of the same coin.
Nucleosome positioning and nucleosome stacking: two faces of the same coin.
Mol Biosyst. 2012 Jan 23. [Epub ahead of print]

PubMed
Endovascular treatment of patients with chronic cerebrospinal venous insufficien...
Endovascular treatment of patients with chronic cerebrospinal venous insufficiency and multiple sclerosis.
Georgian Med News. 2011 Oct ;(199):29-34.

PubMed
Interactive tree comparison for co-located collaborative information visualizati...
Interactive tree comparison for co-located collaborative information visualization.
IEEE Trans Vis Comput Graph. 2007 Nov-Dec ;13(6):1232-9.

PubMed
DUFs: families in search of function.
DUFs: families in search of function.
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Oct 1 ;66(Pt 10):1148-52. Epub 2010 Mar 5 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: