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J Exp Med. 2011 Jun 6;208(6):1189-201. doi: 10.1084/jem.20101823. Epub 2011 May 9.

miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice.

Author information

  • 1Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA. mboldin@coh.org

Abstract

Excessive or inappropriate activation of the immune system can be deleterious to the organism, warranting multiple molecular mechanisms to control and properly terminate immune responses. MicroRNAs (miRNAs), ∼22-nt-long noncoding RNAs, have recently emerged as key posttranscriptional regulators, controlling diverse biological processes, including responses to non-self. In this study, we examine the biological role of miR-146a using genetically engineered mice and show that targeted deletion of this gene, whose expression is strongly up-regulated after immune cell maturation and/or activation, results in several immune defects. Collectively, our findings suggest that miR-146a plays a key role as a molecular brake on inflammation, myeloid cell proliferation, and oncogenic transformation.

PMID:
21555486
[PubMed - indexed for MEDLINE]
PMCID:
PMC3173243
Free PMC Article
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