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Neuron. 2011 May 12;70(3):410-26. doi: 10.1016/j.neuron.2011.04.009.

The many faces of tau.

Author information

  • 1Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA.

Abstract

While the microtubule-binding capacity of the protein tau has been known for many years, new functions of tau in signaling and cytoskeletal organization have recently emerged. In this review, we highlight these functions and the potential roles of tau in neurodegenerative disease. We also discuss the therapeutic potential of drugs targeting various aspects of tau biology.

Copyright © 2011 Elsevier Inc. All rights reserved.

PMID:
21555069
[PubMed - indexed for MEDLINE]
PMCID:
PMC3319390
Free PMC Article

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