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Biol Psychol. 2011 Jul;87(3):366-71. doi: 10.1016/j.biopsycho.2011.04.007. Epub 2011 May 7.

Gene environment interactions with a novel variable Monoamine Oxidase A transcriptional enhancer are associated with antisocial personality disorder.

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  • 1Department of Psychiatry, The University of Iowa, Iowa City, IA, USA. robert-philibert@uiowa.edu

Abstract

Monoamine Oxidase A (MAOA) is a critical enzyme in the catabolism of monoaminergic neurotransmitters. MAOA transcriptional activity is thought to be regulated by a well characterized 30 base pair (bp) variable nucleotide repeat (VNTR) that lies approximately ∼1000 bp upstream of the transcriptional start site (TSS). However, clinical associations between this VNTR genotype and behavioral states have been inconsistent. Herein, we describe a second, 10 bp VNTR that lies ∼1500 bp upstream of the TSS. We provide in vitro and in silico evidence that this new VNTR region may be more influential in regulating MAOA transcription than the more proximal VNTR and that methylation of this CpG-rich VNTR is genotype dependent in females. Finally, we demonstrate that genotype at this new VNTR interacts significantly with history of child abuse to predict antisocial personality disorder (ASPD) in women and accounts for variance in addition to that explained by the prior VNTR.

Copyright © 2011 Elsevier B.V. All rights reserved.

PMID:
21554924
[PubMed - indexed for MEDLINE]
PMCID:
PMC3134149
Free PMC Article
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