Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Forensic Sci. 2011 Sep;56(5):1346-8. doi: 10.1111/j.1556-4029.2011.01794.x. Epub 2011 May 6.

Congenital tetragametic blood chimerism explains a case of questionable paternity.

Author information

  • 1Shenzhen Institute of Transfusion Medicine, Shenzhen Blood Center, Nigang Xi Road, Meigang Nan Street, Shenzhen 518035, Guangdong, China.

Abstract

Human chimerism is the presence of ≥ 2 cell populations in one person that contain genetic material from more than one zygote. Chimerism may be either acquired by transfusion or transplantation of donor cells, or congenital arising from embryo fusion or dizygotic twin-twin transfusion. We encountered a 4-year-old boy with developmental hip dysplasia whose preoperative (serologic) blood group was AB, but whose red cell agglutination was atypical ("mixed field") and caused us to study the patient's parents' ABO blood groups. Parental blood groups (AB and O) suggested possible nonparentage. An alternative explanation of the findings was that the child was chimeric or mosaic. Molecular cloning and genotyping of his ABO locus in leukocytes revealed two heterozygous genotypes: A102/O01 and B101/O01. Other loci, each of which possessed three distinct alleles, unambiguously showed transmission of two alleles from either the child's mother (e.g., HLA-A) or two alleles from the child's father (e.g., D8S1179). Findings indicate that the child is a tetragametic chimera.

© 2011 American Academy of Forensic Sciences.

PMID:
21554308
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Write to the Help Desk