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Cancer Causes Control. 2011 Jul;22(7):1003-10. doi: 10.1007/s10552-011-9773-0. Epub 2011 May 7.

Association between psoriasis and incident cancer: the Iowa's Women's Health Study.

Author information

  • 1Division of Epidemiology and Community Health, University of Minnesota, 1300 2nd Street South, Suite 300, Minneapolis, MN 55455, USA. prizm001@umn.edu

Abstract

INTRODUCTION:

Studies have reported higher cancer risk in individuals with psoriasis, a chronic inflammatory autoimmune disease; however, adjustment for potential confounders was lacking.

METHODS:

We examined the association of psoriasis with cancer incidence in 32,910 women after age 65 in the IWHS cohort linked to Medicare. Psoriasis was defined as: 2+ psoriasis claims from any Medicare file during 1991-2004 or 1+ psoriasis claim from a dermatologist (n = 719). Severe psoriasis was defined as 4+ psoriasis claims from a dermatologist in any year (n = 121). Cox proportional hazards regression, with psoriasis as a time-dependent variable was conducted to calculate hazard ratios (HR) and 95% confidence intervals (CI) of total (n = 6,488), breast (n = 2,066), lung (n = 742), and colon cancers (n = 947).

RESULTS:

With age-adjustment, psoriasis (yes vs. no) was associated with increased risk of lung 1.9 (95% CI: 1.2-3.0), colon 1.6 (95% CI: 1.1-2.5), and total cancer 1.2 (95% CI, 1.0-1.4). After further adjustment for smoking, body mass index, education, physical activity, and hormone therapy use, only the association for colon cancer remained statistically significant (HR = 1.6, 95% CI: 1.0-2.4) and was stronger for severe psoriasis.

CONCLUSION:

The observed association between psoriasis and colon cancer may reflect inflammatory or unidentified processes.

PMID:
21553077
[PubMed - indexed for MEDLINE]
PMCID:
PMC3175809
Free PMC Article

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