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  • PMID: 21552172 was deleted because it is a duplicate of PMID: 21900810
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Neurosurgery. 2011 Oct;69(4):864-8; discussion 868-9. doi: 10.1227/NEU.0b013e318222adfa.

Postoperative infection may influence survival in patients with glioblastoma: simply a myth?

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  • 1Institutes of Neuro-surgery, Catholic University School of Medicine, Rome, Italy. debonisvox@gmail.com

Abstract

BACKGROUND:

It is a prevalent myth that a postoperative infection may actually confer a survival advantage in patients with malignant glioma. This contention is based largely on anecdotal reports. Recently, a single-center study showed there was no survival advantage in those patients who had glioblastoma with postoperative infection.

OBJECTIVE:

To examine the impact of postoperative infections on outcome in patients with glioblastoma treated at our center.

METHODS:

This study included 197 patients with newly diagnosed primary glioblastoma treated from January 2001 to January 2008. Of the 197 patients, 10 (5.08%) had postoperative bacterial infection. The Kaplan-Meier method, log-rank test, and Breslow test were used in the univariate approach; Cox regression was used in the multivariable approach.

RESULTS:

The median survival was 16 months (95% confidence interval [CI], 14-18 mo). The infection group had a significant advantage in the median survival: 30 months (95% CI, 21-39) vs 15 months (95% CI, 13-17) for patients without postoperative infection. This advantage was also confirmed by Cox regression; in fact, patients not developing a postoperative infection showed an adjusted hazard ratio for death of 2.3 (95% CI, 1-5.3).

CONCLUSION:

The association between infection and prolonged survival is not definitive; we acknowledge the considerable difficulties in undertaking this type of study in a retrospective manner. Our results can instead stimulate further multicentric studies (to increase the number of patients) or experimental studies using genetically modified bacteria for treatment of glioblastoma.

PMID:
21900810
[PubMed - indexed for MEDLINE]
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