Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Science. 2011 May 6;332(6030):680-6. doi: 10.1126/science.1198701.

Scaffold proteins: hubs for controlling the flow of cellular information.

Author information

  • 1Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.

Abstract

The spatial and temporal organization of molecules within a cell is critical for coordinating the many distinct activities carried out by the cell. In an increasing number of biological signaling processes, scaffold proteins have been found to play a central role in physically assembling the relevant molecular components. Although most scaffolds use a simple tethering mechanism to increase the efficiency of interaction between individual partner molecules, these proteins can also exert complex allosteric control over their partners and are themselves the target of regulation. Scaffold proteins offer a simple, flexible strategy for regulating selectivity in pathways, shaping output behaviors, and achieving new responses from preexisting signaling components. As a result, scaffold proteins have been exploited by evolution, pathogens, and cellular engineers to reshape cellular behavior.

PMID:
21551057
[PubMed - indexed for MEDLINE]
PMCID:
PMC3117218
Free PMC Article

Images from this publication.See all images (6)Free text

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Box 1
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk