Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Trends Cell Biol. 2011 Jun;21(6):354-61. doi: 10.1016/j.tcb.2011.04.001. Epub 2011 May 6.

Long noncoding RNAs and human disease.

Author information

  • 1Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford, CA 94305, USA.

Erratum in

  • Trends Cell Biol. 2011 Oct;21(10):561.

Abstract

A new class of transcripts, long noncoding RNAs (lncRNAs), has been recently found to be pervasively transcribed in the genome. Multiple lines of evidence increasingly link mutations and dysregulations of lncRNAs to diverse human diseases. Alterations in the primary structure, secondary structure, and expression levels of lncRNAs as well as their cognate RNA-binding proteins underlie diseases ranging from neurodegeneration to cancer. Recent progress suggests that the involvement of lncRNAs in human diseases could be far more prevalent than previously appreciated. We review the evidence linking lncRNAs to diverse human diseases and highlight fundamental concepts in lncRNA biology that still need to be clarified to provide a robust framework for lncRNA genetics.

Copyright © 2011 Elsevier Ltd. All rights reserved.

PMID:
21550244
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk