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    Arch Pathol Lab Med. 1990 Mar;114(3):298-303.

    The significance of HIV-1-indeterminate western blot results in blood donor populations.

    Source

    American Red Cross Blood Services, Los Angeles, Orange Counties Region, CA 90006.

    Abstract

    Until recently it has been difficult to counsel blood donors with human immunodeficiency virus-1 (HIV-1)-indeterminate Western blot results due to a lack of information concerning the significance of this finding. Reports from several investigators have provided laboratory, epidemiologic, and prospective follow-up data that have clarified the potential significance of this laboratory finding. It has been established that the band patterns observed in an HIV-1-indeterminate Western blot result are important in predicting the significance of the result; specifically, the absence of p24 or envelope glycoprotein reactivity has not been associated with HIV-1 infection, whereas the presence of p24 reactivity has infrequently been the first sign of HIV-1 seroconversion. These data provide the basis for formulating policies concerning the notification and counseling of blood donors with HIV-1-indeterminate Western blot patterns.

    PMID:
    2154962
    [PubMed - indexed for MEDLINE]

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