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    Dermatol Online J. 2011 Apr 15;17(4):15.

    Two cases of refractory discoid lupus erythematosus successfully treated with topical tocoretinate.

    Abstract

    Discoid lupus erythematosus (DLE), the most common lupus erythematosus (LE)-specific chronic manifestation of the skin, is often resistant to therapy. Atrophy, scarring, and pigmentation are often observed. In this study, we report two cases of DLE that were successfully treated with tocoretinate, a compound containing a mixture of retinoic acid and tocopherol. Atrophy and pigmentation improved in both cases. The mechanism of action of tocoretinate is discussed.

    PMID:
    21549090
    [PubMed - indexed for MEDLINE]
    Free full text

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